At what point is it OK to give up on certain jobs and people?

You're not supposed to quit or walk on certain topics, but ya know what? Sometimes it's OK to.

You might read that headline and think "Never!" either because "Work is virtue" or "Relationships are life!" The latter is closer to true than the former, but neither is 100 percent true.

Anyway, here's what I mean:

Small personal example: I have a friend from college, mini-media celebrity these days (holler!) and even back in 2006, when he was hustling a…